CEREBRAL ASSIST DEVICE FOR CBF AUGMENTATION AND ICP REDUCTION
Reduced cerebral blood flow (CBF) and oxygen delivery to the brain is a common final pathway for lethal and highly debilitating pathologies such as traumatic brain injury (TBI), stroke and cerebral vasospasm. Intracranial pressure (ICP) level was shown to correlate with outcome due to its constricting effect on blood vessels.
Present interventions include cerebrospinal fluid (CSF) drainage, endovascular and/or surgical management of hematoma(s) and systemic pharmacological and hemodynamic management. In particular, CSF drainage utilizes an external ventricular drain (EVD) and is expected to temporarily reduce ICP thereby restoring blood flow, yet a major problem is brain edema, directly resulting from the parenchymal/vascular insult and is hardly alleviated by CSF drain. Hence, a major treatment goal is restoring impeded oxygen supply to brain tissue by increasing blood flow.
SynCath Neuroscience is a preclinical stage MedTech startup, encapsulating assets of a groundbreaking research program, initiated and led by Prof Ofer Barnea and Dr Omer Doron. Our proprietary technology is based on an ECG-synchronized dynamic ICP-modulation. The technology is realized via a disposable, autonomous ICP modulation probe. The probe is in-dwelling, ECG-synchronized and delivered via an EVD (external ventricular drain) like catheter.
The underlying physical mechanism is that externally-superimposed fine volume perturbations can be used to enhance CBF by synchronized deflate-inflate actions within each cardiac cycle. SynCath will initially address patients instrumented with an EVD. The most frequent single indication for placement of an EVD is TBI (traumatic brain injury).
Complete development of product prototype
Develop and validate the numerical modeling for the technology
Optimized the ECG-synchronization, pressure-stimulation waveform and intensity for the naïve porcine animal model
Setup and adapted two “gold standard” porcine disease animal models for TBI (traumatic brain injury)
Tested and optimized the therapeutic stimulation protocols in a large cohort of disease model pigs
Landmark paper in Journal of Neurosurgery: Doron O et al. "Cerebral blood flow augmentation using a cardiac-gated using an intracranial pulsating balloon pump in a swine model of elevated ICP"
MEET THE TEAM
Prof. Ofer Barnea
Professor of Biomedical Engineering and former chairman of the Department of BME at TAU. BSc in EE@TAU; PhD in BME at Drexel. 30 years experience in the medical device industry. Founded several companies and led the development of medical devices as a consultant
Dr Omer Doron, MD
Neurosurgery Resident, Hadassah University Medical Center, Jerusalem. PhD candidate, Dept. of BME, TAU. Author of several peer-reviewed papers in neurosurgical journals. Past : Airborne Doctor in the IDF.
Dr. Ofer Hornik, MD
A physician in training, with 25 years of program management, product management, clinical & regulatory management, entrepreneurial, and executive positions in numerous healthcare startup companies.
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